I have not found to many media type properties that made good TCG's. The original Lord of the Rings game was pretty good but became complicated after awhile. Same thing with the Star Wars one. Too many new rules with each new set released. By themselves I thought the mechanics were fun but when placed together in the game it didn't seem interesting anymore.
I think WOTC knows this and I am sure the Simpsons game will be more a specialty item than anything else. I doubt if they intend to do more than one expansion to it. Futurama could be a fun game but I think you would have to build it around the Planet Express ship and make it more like Shadowrunner where the goal of the game is to make deliveries. The other players would try to stop you from making these deliveries and you would have to use your own resources to combat them, fix the ship as well as pay for star fuel and so forth.
Anyways, this thread is not supposed to be about TCG's but about Futurama trading cards. Sorry for getting so off topic on my part.
Just to reiterate my thoughts - I am all for it!