Wouldn't mind that at all!
Or maybe a role reversal. Have Fry be a tough guy robot, and Bender be the dumb delivery boy. Amy the spaceship captain, and Leela the fun loving rich girl intern! Zoidberg is the beloved beaucrat and Hermes is the lowly doctor! Scruffy is the Professor and Farnsworth is the janitor!
This would be fun: All the exes of the PE Crew take over PE. Michelle is the delivery girl, Fanny is the robot, Zapp is the captain, Mom is the Professor, the bisque guy from the Titanic episode is the intern, and Edna is the doctor. Not sure if Hermes had another girlfriend before Labarbra, though.