Best comebacks in the show?

[on:]

What do you think are the most satisfying clapbacks/rebuttals/comebacks in the show?

Here are some of mine.

iBev: I ain't making no drinks for no trashy robo sluts.
Esther (without missing a single beat)
Trashy??? At least I don't put out for quarters. 

Cubert: Why do I have to be the hump?!?!?
Fry: Because you are too ugly to be a wart.

Amy: C'mon Leela, every girl dreams of being Miss Universe.

Leela: I never did something that pathetic.

Amy: Oh.  Guess it was just the cute girls.

Sal: Nice eyeball, eyeball.

Leela: Nice ass, ass.

[Reply #1 on:]

Not so much a comeback, and not in great taste perhaps, but

April: You, wrinkled as a prune.
Professor: You, fat as the queen of sea cows.

[Reply #2 on:]

I always get a kick out of this exchange from "Into the Wild Green Yonder," which is sort of a two-fer from Leo...

Amy: I knew you wanted a son! Why do you think I became a miniature golf champion? Why do you think I wear these stupid boys' sweat suits?

Leo Wong: To hide your big, fat butt, that's why.

Fry: Now, sir, in fairness, Amy's butt is actually pretty hot.

Amy: What is it with you men? Why does everything revolve around my butt?

Leo: 'Cause it's so big and massive.

[Reply #3 on:]

Not so much a comeback, and not in great taste perhaps, but

April: You, wrinkled as a prune.
Professor: You, fat as the queen of sea cows.

Sometimes the Glados approach to weight works with how brutal it is.   Apparently I made one of my sisters cry when I was little.

Sister: You are an ugly little brat.

Me: Well you weigh 18 tonnes.

Another time I was four and she said something and I just snapped "If you opened the fridge door less there would be less of you to hate!"   No wonder she used to beat me up so much.

Oh and I forgot Fry has quite a few zingers.   For a "stupid" guy Fry has some witty comebacks and can really throw some shade when he wants to.

"How come I have to be the hump?"

"Because you are too ugly to be a wart."

Bender cackles and Leela snickers.

[Reply #4 on:]

Not necessarily a comeback but I always enjoyed the casual but potentially devastating cruelty of lines like "Enough about your promiscuous mother, Hermes!" from the Professor.

[Reply #5 on:]

Sometimes the Glados approach to weight works with how brutal it is.   Apparently I made one of my sisters cry when I was little.

Sister: You are an ugly little brat.

Me: Well you weigh 18 tonnes.

Another time I was four and she said something and I just snapped "If you opened the fridge door less there would be less of you to hate!"   No wonder she used to beat me up so much.

I suppose that you could have told her that if she worked harder at beating you up she might have burned enough calories to lose a few pounds, but I doubt that you would have enjoyed the results.