I don't like the idea of Fry giving up chasing Leela. If THAT isn't a major reset, nothing is. And as for Leela recovering her memory and wondering why Fry doesn't seem to remember her declaration of love...a problem that could be cleared up in a minute if the pair just TALKED to each other about it...that sounds like ye olde miscommunication gimmick, the basic formula for "Three's Company".
Come and knock on our door...we've been waiting for you..
Uh, uh, no thank you.
I didn't say _I_ liked it either, I said it was my bet
Though I might also put a fiver on start-off-remembering-everything-and-all-is-well (first few eps), things-get-messed-up-and-they-dump-each-other (middle eps), things-resolve-they-get-back-together (final eps).
Now, when it's better than either of those scenarios I'll get a nice surprise, and if it's worse at least I'll be sort-of prepared for it. Lowered expectations are the best!:D